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Persistent oxidative stress and ROS play crucial roles in the onset of diseases

It exhibits resistance to enzymatic degradation in certain experimental conditions, which has made it an attractive compound for studies involving peptide stability and systemic biological activity

276 Tirzepatide is associated with significantly greater proportion of achieving MASH remission with no worsening of fibrosis compared with placebo 277 in a phase 2 trial, and another phase 2 trial for dual agonism of glucagon receptor and GLP-1R (GCGR/GLP-1RA) survodutide demonstrated similar improvements in MASH

Mol Neurobiol 35:203216 Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Tripoli DL, Czerniewski L, Ballabio A, Cirrito JR, Diwan A, Lee JM (2015) Neuronal-targeted TFEB accelerates lysosomal degradation of app, reducing A generation and amyloid plaque pathogenesis