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Therefore, AGE is believed to cause harmful effects in the endoneurium, primarily through direct toxicity to nerve tissues and contributing to endoneurial microangiopathy
72 N--acetyltransferase (NAT) family N--acetyltransferase 10 (NAA10), as a catalytic subunit of N-acetyltransferase A (NatA), has been documented to acetylate lysine residues of several protein substrates, including hypoxia-inducible factor 1 alpha (HIF-1), Runt-related transcription factor 2 (Runx2), -catenin, and myosin light-chain kinase
These unstable molecules are called free radicals, and the oxidative damage they cause can increase the risk of heart disease, liver disease, some cancers, and other conditions
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