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EPA and DHA are the most broadly anti-inflammatory supplements available
Eric Topol (35:30): Yeah, I think the way you prep the patients who go for it is so critical because I have so many patients I know you have who have had to go through all these extra tests, biopsies and whatnot, and came at everything negative, but the anxiety they went through was profound
Sleep optimization during retatrutide use: Stop eating 3-4 hours before bed to prevent acid reflux from disrupting sleep Supplement magnesium glycinate (400-600mg) before bed for both sleep quality and muscle recovery Maintain consistent sleep and wake times Consider melatonin (0.5-1mg) if sleep onset is delayed Monitor sleep quality with a wearable device to quantify the impact and adjust dosing if needed Cardiovascular considerations for athletes The documented increase in resting heart rate (up to 10 bpm in one case) and reduced heart rate variability are concerning for athletes who rely on cardiovascular efficiency for training performance
These medications can sometimes trigger dry mouth, acid reflux, tooth sensitivity, and even enamel wear
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