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His framing is that methylation is foundational: if the body can't methylate efficiently, it can't detoxify, produce neurotransmitters, or repair DNA the way it's supposed to
doi:10.1007/s00726-006-0477-9 Blachier F, Wu G, Yin Y (2013) Nutritional and physiological functions of amino acids in pigs
These effects are more likely at higher doses, particularly above 3,000 mg per day, and taking supplements with food can help reduce gastrointestinal discomfort
It has been shown that rhein inhibits CYP2C9, CYP1A2, CYP2E1, CYP2D6 and CYP3A enzymes in rat liver (Tang et al., 2009)
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