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The expression of six key metabolic enzymesphenylalanine hydroxylase (PAH), tyrosine aminotransferase (TAT), 4-hydroxyphenylpyruvate dioxygenase (HPPD), homogentisate 1,2-dioxygenase (HGD), glutathione S-transferase zeta 1 (GSTZ1), and fumarylacetoacetate hydrolase (FAH)is downregulated

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