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In addition, the iron-containing metal-organic framework TPL@TFBF is formed through the coordination of tannic acid (TA) with Fe + , loaded with triptolide (TPL) and coated with FA-modified BSA, among them TPL increases intracellular ROS production by inhibiting the expression of Nrf2, leading to ferroptosis and pyroptosis, releasing a large amount of DAMPs, which in turn stimulates DCs antigen presentation and CD4 + /CD8 + T cell proliferation thereby suppressing tumor growth and metastasis (227)
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Future studies including both male and female offspring, with adequate power to evaluate sex-by-treatment interactions, are needed to determine whether LipRSV produces sex-specific behavioral and biochemical effects
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