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In Stevens-Johnson syndrome and toxic epidermal necrolysis, keratinocytes exhibit imbalanced FSP1-CoQ10 antioxidant systems and increased lipid peroxidation, leading to ferroptosis and life-threatening skin adverse drug reactions characterized by keratinocyte death [93]
Increasing should be based on careful assessment of response, not impatience for faster results
The grid below lays out a twice-daily (fasted AM + pre-bed) example so the two patterns are easy to compare across the week: On the continuous twice-daily pattern, a full week is 14 doses 100 mcg = 1,400 mcg (1.4 mg)
others use them occasionally for a boost.
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