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Cell 169:361371 Schwarten M, Berghaus C, Heumann R, Stoll R (2007) Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb
London: Longmans, Green and Co
Its working mechanism is allosteric facilitation of HGF/c-Met signaling: Dihexa binds HGF with high affinity (reported K d ~65 pM in the original work) and is proposed to potentiate HGF dimerization and c-Met phosphorylation at subthreshold endogenous HGF concentrations
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