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2.5.9.3 Orismilast Orismilast (UNI-50001) is an oral B/D selective PDE-4 inhibitor being studied for moderate to severe UC in the UCORIS trial, a Phase 2a open-label single-arm exploratory study that enrolled adults with UC diagnosed for at least 3 months, MES of 2, on stable 5-ASA or immunomodulator therapy for 3 months, with treatment given twice daily for 12 weeks extendable to 52 weeks (81, 82)

Lifestyle modifications diet, exercise, and behavioral strategies remain essential for optimizing and sustaining results regardless of which medication is used

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