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doi: 10.1111/nep.14149 82 KoppeL.FouqueD.SoulageC
As GLP-1R mRNA in the aortic tissue was below the level of quantification in both animal models, it seems likely that GLP-1Rs in other tissues, rather than direct action of liraglutide or semaglutide on the vascular bed, contribute to the mechanism of gene regulation
However, at partial or subtherapeutic doses, patients may feel partial benefits, such as mild appetite suppression and small changes in blood sugar levels and weight loss
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