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Eating smaller meals, avoiding high-fat foods, and staying hydrated all help manage these symptoms

One mechanism underlying these benefits is the activation of adenosine A receptors by paeoniflorin: A receptor stimulation has neuroprotective effects, and paeoniflorins ability to activate this pathway is linked to reduced neuroinflammation and improved dopamine neurotransmission in toxin-induced PD models (37)

Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is expected to be regained over the next 5 years [4, 5]