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4 Future challenges 4.1 Mechanistic validation across ocular pathologies Despite progress in understanding molecular pathways such as calcium channel modulation and mitochondrial mitophagy, the relative contributions of these mechanisms to specific diseases remain unclear

Smallpox/Monkeypox vaccination and developed complications Wait 14 days after all vaccine complications have resolved or 8 weeks (56 days) from the date of having had the smallpox vaccination whichever is the longer period of time

For people with type 2 diabetes who are also taking insulin or sulfonylureas, the risk is substantially higher and requires active monitoring and likely dose reductions of the diabetes medications as weight and blood glucose improve

Reddy Laboratories, grants from Novartis, grants and personal fees from PCORI, grants from Scion, grants and personal fees from Teva, grants from Zosano, personal fees from Promius, personal fees from Biohaven, personal fees from Theranica, and grants from Satsuma, outside the submitted work