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doi: 10.1056/NEJMoa072375 126 PandyaNDeMott-FribergRBowersCYBarkanALJaffeCA
Unlike medications that target a single hormone pathway, retatrutide works on three separate receptors that influence hunger, fullness, and metabolism
Rat studies have noted embryofetal mortality, structural abnormalities, and alterations to growth at maternal exposures below the maximum recommended human dose (MRHD) based on exposure AUC
It differs from IGF-1 by additional 13 amino acids at the N-terminus and the substitution of arginine with glutamic acid at the 3rd position
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