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10,11,15 Aging skin displays fragmentation of collagen and elastin fibers by the action of matrix metalloproteinase (MMPs), and increased mitochondrial oxidative stress results in deletions of mitochondrial DNA via the c-Jun/AP-1 pathway in dermal fibroblasts (Figure 1)
Wang X, Chen S, Xia X, Du Y, Wei Y, Yang W, et al
Ketogenic diet induces p53-dependent cellular senescence in multiple organs
Their combined use in research models is designed to stimulate GH secretion via dual-pathway activation
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