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These two drugs were not only able to enrich GSH contents and GPX activity and defend the heart against oxidative stress but also prevented DOX or I/R-induced myocardial injury [214,215,216,217]
DSVs actively generate hydrogen sulfide (H2S) through sulfate reduction by utilizing sulfate as an electron acceptor during the respiration and increase H2S production, which causes severe damage to the CNS (78)
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One observation from our studies is the fact that the supplementation with LOX and/or BMP1 drastically reduced the accumulation of the soluble form of secreted collagen, but this reduction was translated to collagen deposition only when cells were concomitantly stimulated with TGF-1
