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These findings provided external support for TCMR-associated T-cell metabolic transcriptional remodeling, although the limited number of validation biopsies precluded definitive statistical validation
In some cases, like acetaminophen overdose, the mechanism is well established
Off / washout (after the block): A typical research framing runs a defined block (commonly 812 weeks) followed by an off period before any subsequent block, rather than indefinite continuous use because long-term human data simply do not exist
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