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Cyclically demethylated and methylated CGs of the estrogen-responsive pS2 gene are inside the CG-poor region (Metivier et al., 2008)
The general principle these definitions reflect is a pharmacokinetic property rather than a dosing instruction: with a half-life of roughly one week, exposure declines gradually rather than abruptly across a shifted or missed interval
That taking GLP-1s is a cop out, or an "easy" route to weight loss
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