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6 This deficiency is particularly concerning for GLP-1 users who may experience gastrointestinal side effects like diarrhea (5-36% of semaglutide users) and constipation (5-37% of semaglutide users)

We did not restrict our study to patients who were highly adherent with their medication either, which may better reflect the utility of these medications in every day clinical practice. White and colleagues collected electronic health records and health insurance claims data from 2,405 adults aged 18 years and older receiving care at a large health care system in western Pennsylvania who were dispensed a GLP-1 receptor agonist from 2011 to 2018 (mean age, 48 years