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It's important to understand the difference between the two
The development of 3D culture models and organ-on-chip platforms brought a degree of complexity to classic in vitro for more physiological models of organs including the BBB
For instance, ketogenic diets or ketone supplements alter the production of GLP-1 ( GLP-1 is produced together with anorexigenic peptide GIP, and the combination of the GLP-1R agonist and GIP synergistically reduces the level of feeding and body weight
Moreover, SCFAs were shown to augment the production of leptin which, as discussed above, was found to be decreased in disorders marked by impulsivity, thus linking SCFAs with psychiatric conditions (169)
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