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Its clear that we need more research evaluating the impact of these drugs on eating disorders outside of binge-eating disorders, but this could take a long time
The study reported that participants "regained two-thirds of their prior weight loss." A meaningful share of the loss is muscle: across body-composition studies, roughly a quarter of the weight lost is lean mass (muscle), with the rest fat (Karakasis and colleagues, network meta-analysis, Metabolism , 2024), and the honest range landing between about 15% and 40% (Hierholzer and colleagues, review, 2026)
How Long Does Semaglutide Fatigue Last Most patients report that semaglutide-related fatigue peaks within the first 1-2 weeks of starting treatment or after each dose increase, then gradually improves over 2-4 weeks