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Given that the negative symptoms and cognitive deficits noted in schizophrenia are linked with reduced D1-dopaminergic signaling, PDE1B inhibitors are considered promising molecules for schizophrenia due to their potential to elevate D1-dopaminergic signaling (Figure 2) (Winterer, 2006)

1 Introduction There is a growing demand on fermented foods globally and the size of the global fermented food and beverages market was US$ 575.6 Billion in 2022 and is expected to increase at a compound annual growth rate of 5.6%, reaching around US$ 989.2 Billion by 2032 (1)

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A Cerami designed the trial, participated in data analysis and wrote the paper