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Tolerance and response: a provider adjusts based on how a patient actually responds over time, which no static number can anticipate
In placebo-controlled trials for type 2 diabetes mellitus, an injection site reaction (e.g., injection-site discomfort, erythema) was reported in 0.2% of patients receiving semaglutide
While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers
These adaptations may explain why metabolic benefits can continue to improve over weeks to months of consistent use, rather than plateauing immediately
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