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In vitro , HSYA reduced VEGF-C expression and secretion in Raw264.7 cells, attenuated macrophage uptake of ox-LDL cholesterol, downregulated AKT/mammalian target of rapamycin and NF-B signaling via PI3K inhibition, and mitigated lymphangiogenesis and inflammation, providing comprehensive protection against atherosclerosis
TH17 cells release IL-17 and IL-22, which activate keratinocytes
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