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The predefined protocol of the present study was registered in the International Prospective Register of Systematic Reviews ( PROSPERO : identifier CRD42023469511)
396 Moreover, demethylation treatment can disrupt protein methylation, leading to the accumulation of SAH while depleting cellular SAM, resulting in the inhibition of autophagy and apoptosis induced by endoplasmic reticulum stress in pancreatic cancer cells
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Such combined strategies could mitigate the inflammatory milieu and improve both spermatogenic and erectile functions
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