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This observation may be partially attributed to the predominance of gynoid fat distribution localized to the hips, buttocks, and legs which has been associated with reduced insulin resistance when compared to central or android fat accumulation.15,25 Similarly, blood pressure measurements in women with early-stage lipedema tend to remain within normal ranges, with hypertension primarily observed in more advanced stages

That doesn't mean the results are unreliable, but it does mean a careful read is required

Patients taking GLP-1 medications were about 9x more likely to develop pancreatitis and over 4x higher risk of bowel obstruction compared to those on bupropion-naltrexone, the study found