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362 Excess copper binds PDK1 and enhances its interaction with AKT, activating the AKT/GSK3/-catenin cascade

/wk Weeks 1-4 Starting dose /wk Weeks 5-8 First increase /wk Weeks 9-12 Therapeutic level /wk Weeks 13-16 Near target /wk Weeks 17-20 Higher dose /wk Week 21+ Maximum Side Effects & Safety Side effects are similar to other GLP-1 medications and typically improve over time