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By blocking receptor activity, these medications prevent other substances from causing a high, making the substances ineffective and relapse less likely
The mixed results emphasize the need for further research to determine how GLP-1 medications may be used to treat OUD and other substance use disorders
Overall, these findings demonstrate that this substrate profiling system can both predict and validate physiologically relevant off-target cleavage events, thereby providing critical information for refining protease specificity for intended applications
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