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However, note that the trials had short follow-up and did not evaluate cancer outcomes
El dato animal de Tomas 1993 Tomas 1993 (Long-R3-IGF-1) administr Long-R3-IGF-1 subcutneo a ratas en restriccin calrica y report: Aumento significativo de ganancia de peso vs ratas controles a dieta similar Retencin de nitrgeno indicando preservacin de masa magra Eficacia mayor que IGF-1 nativo a dosis equimolar (consistente con la potencia in vitro 3) El hallazgo es mecansticamente coherente : ms IGF-1 libre ms seal en IGF-1R ms anabolismo en msculo y otros tejidos receptivos
Wedlake L, A'Hern R, Russell D, et al
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