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Despite production costs being estimated at under $5 per month, the branded pricing creates a substantial financial barrier, especially for patients requiring chronic therapy
Berberine may also slow gastric motility in some individuals, and since GLP-1 medications already delay stomach emptying, this combination could theoretically increase digestive side effects such as nausea, constipation, or bloating
In addition, the supplementation of selenium, alone or together with vitamin E, did not show any benefits regarding the risk of prostate, lung, or colorectal cancers after 5.5 years of follow-up (86, 87)
Exercise recovery improves noticeably, with reduced muscle soreness and faster return to baseline after workouts
