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Abbreviations hTERT: Telomerase reverse transcriptase HDR: Homology-directed DNA recombination VEGF: Vascular endothelial growth factor TRF2: Telomeric repeatbinding factor 2 IVF: In vitro fertilization PrEC: Prostate epithelial cells MAPK: Mitogen-activated protein kinase AR: Androgen receptor PSA: Prostate-specific antigen BPH: Benign prostate hyperplasia BAT: Bipolar androgen therapy DHT: Deprivation of dihydrotestosterone ADT: Androgen deprivation therapy CRPC: Castration-resistant PCa LAL: Low androgen level SAL: Supraphysiological androgen level pARE: Positive androgen response element PBMCs: Peripheral blood mononuclear cells TRF1: Telomere repeat-binding factor 1 TRF2: Telomere repeat-binding factor 2 POT1: Protection of telomeres TIN2: TRF1-interacting nuclear factor 2 PKA: Protein kinase A GnRH: Gonadotropin releasing hormone EGF: Epidermal growth factor HER2: Human epithelial growth factor 2 FGFs: Fibroblast growth factors TGF-: Transforming growth factor- IGF-I: Insulin-like growth factor 1 DIZ-3: Dimeric aryl-substituted imidazole ncRNAs: Non-coding RNAs miRNAs: MicroRNAs TERC: Telomerase RNA component TERRA: Telomere repeat-containing RNA References Bartlett Z

The added materials inevitably block active site centers and cause adverse mass and electron transport, leading to suppressing the OER/HER electrocatalytic activity and durability