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Effects on the kidneys and fluid balance Some evidence suggests GLP-1 therapies may increase natriuresis (excretion of sodium in urine), which can support blood pressure and reduce fluid-related strain

Lesions may be flat or raised and can occur anywhere on the body, including hidden areas such as under the nails or on the soles of the feet

By inhibiting the enzyme tyrosinase, glutathione helps reduce melanin synthesis, leading to a brighter, more even complexion

NCT06588296 (TOGETHER-PsA) (80) is a Phase 3b, randomized, multicentre, open-label study examining the efficacy and safety of ixekizumab compared to ixekizumab concomitantly administered with tirzepatide in overweight or obese adult patients with active PsA and at least one weight-related comorbidity