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A retrospective analysis of 461,382 adults treated with GLP-1 receptor agonists found that nutritional deficiencies were diagnosed in 12.7% of patients within six months and 22.4% within twelve months, with vitamin D deficiency the most common at roughly 13.6% by the one-year mark
Therefore, although a small rise in resting heart rate is measurable, it occurs in the context of meaningful cardiometabolic improvement
The medications work by mimicking the gut hormone GLP-1, making patients feel fuller and limiting appetite
Each may be promoted as the most absorbable or clinically powerful option
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![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)