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For most, safer alternatives such as lifestyle changes, nutrition support, or FDA-approved medical therapies are the better path
However, L-carnitine does not seem to improve depression or quality of life
In murine models of obesity and diabetes, administration of the chemical chaperones phenyl butyric acid (PBA) and tauro-ursodeoxycholic acid (TUDCA), increased systemic insulin sensitivity, established normoglycemia, reduced fatty liver disease, and suppressed inflammatory signaling (137)
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