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Aldosterone induced by AngII promoting the reabsorption of sodium and water from the kidney, can increase water retention, and norepinephrine secretion via positive feedback from the sympathetic end of the anterior membrane, eventually leading to an increase in BP

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To increase the therapeutic effectiveness of GLP-1 in people with type 2 diabetes mellitus (T2DM), attempts have been made to prolong its half-life in the body