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The most honest answer is that we do not yet have every piece of the puzzle
Furthermore, a sedentary lifestyle is associated with a greater risk of HFpEF compared with HFrEF (Pandey et al., 2016)
The relatively slower growth rate and lower growth yield of the wild-type and ghd3 / gdh3 strains on proline or arginine medium, compared to MM medium, can be explained by the fact that amino acids are poor carbon and nitrogen sources in comparison to the glucose and ammonia present in MM medium
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