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Therapeutic targets for treating fibrotic kidney diseases
As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]
68 Cardiac changes include biventricular hypertrophy (RV comprising 67% of heart weight compared with 30% of normal weight), myofiber degeneration, calcification, and mitochondrial damage
[9] Sleep quality and duration profoundly affect metabolic hormones , including those regulating appetite and glucose metabolism
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