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Fiber intake of 30-40 grams daily supports gut bacteria producing short-chain fatty acids that stimulate GLP-1 production
Functionally, GIP receptor activation improves intracellular Ca 2+ concentration, glucagon secretion, and cell depolarization by increasing cAMP/PKA signaling pathways [75, 76]
While Vitamin D is essential to bone health, Vitamin B12 plays a pivotal role in the formation of red blood cells and nerve functions
In this context, several sensors and pathways regulating the transcription factors, such as activator protein 1 (AP-1), cAMP response element-binding protein (CREB), hypoxia inducible factor-1 (HIF-1), nuclear factor B (NF-B), activating transcription factor 4 (ATF-4), and nuclear factor-erythroid 2-related factor-2 (Nrf2), have been described (Marinho et al
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