It's important to seek urgent medical attention if you experience severe, persistent abdominal pain (which could indicate pancreatitis, a rare but serious side effect), persistent vomiting leading to dehydration, or symptoms of gallbladder problems whilst taking these medications
Cardiovascular Protection That Goes Beyond Weight Loss The strongest evidence for this comes from the SELECT trial, which studied patients with preexisting cardiovascular disease and overweight or obesity, but without diabetes
As MC4R deficiency presents with severe obesity from childhood, trials of tirzepatide (NCT06439277 and NCT06075667) and other obesity medications in children and adolescents with obesity, including those with MC4R deficiency, are needed to provide the evidence base for earlier, and potentially chronic, treatment in genetically driven obesity
However, higher doses typically produce stronger appetite suppression, meaning you need to be more intentional about eating