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Helicobacter pylori , a gastric pathogen implicated in peptic ulcers and gastric cancer, secretes the vacuolating cytotoxin (VacA), which localizes to the mitochondrial inner membrane and forms anion-selective channels

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Furthermore, transfection of SH-SY5Y cells with siRNA targeting Rab7a (~ 5076% knockdown efficiency), followed by an incubation with 10% FCS and U18666A (2 g/ml) 50 M compound 10 , strongly reduced the ability of compound 10 to decrease cholesterol accummulation in Rab7-depleted SH-SY5Y cells (Fig